| Thu, Sep 9, 10 | Spread | Moneyline | Total | | WEEK 1 | | Minnesota Vikings | +6 | +200 | | | New Orleans Saints | -6 | -240 |
| Sun, Sep 12, 10 | Spread | Moneyline | Total | | WEEK 1 | | Cincinnati Bengals | +4½ | | | | New England Patriots | -4½ | | | Spread | Moneyline | Total | | WEEK 1 | | Oakland Raiders | +6½ (-115) | | | | Tennessee Titans | -6½ (-105) | | | Spread | Moneyline | Total | | WEEK 1 | | Denver Broncos | +3 (-130) | | | | Jacksonville Jaguars | -3 (+110) | | | Spread | Moneyline | Total | | WEEK 1 | | Cleveland Browns | +3 (-120) | | | | Tampa Bay Buccaneers | -3 (EVEN) | | | Spread | Moneyline | Total | | WEEK 1 | | Detroit Lions | +6½ | | | | Chicago Bears | -6½ | | | Spread | Moneyline | Total | | WEEK 1 | | Carolina Panthers | +7 (-115) | | | | New York Giants | -7 (-105) | | | Spread | Moneyline | Total | | WEEK 1 | | Atlanta Falcons | -2½ | | | | Pittsburgh Steelers | +2½ | | | Spread | Moneyline | Total | | WEEK 1 | | Miami Dolphins | -3 (-125) | | | | Buffalo Bills | +3 (+105) | | | Spread | Moneyline | Total | | WEEK 1 | | Indianapolis Colts | -2½ | | | | Houston Texans | +2½ | | | Spread | Moneyline | Total | | WEEK 1 | | Green Bay Packers | -3 (-115) | | | | Philadelphia Eagles | +3 (-105) | | | Spread | Moneyline | Total | | WEEK 1 | | Arizona Cardinals | -4 | | | | St. Louis Rams | +4 | | | Spread | Moneyline | Total | | WEEK 1 | | San Francisco 49ers | -3 | | | | Seattle Seahawks | +3 | | | Spread | Moneyline | Total | | WEEK 1 | | Dallas Cowboys | -3½ | | | | Washington Redskins | +3½ | |
| Mon, Sep 13, 10 | Spread | Moneyline | Total | | WEEK 1 | | Baltimore Ravens | +2½ | | | | New York Jets | -2½ | | | Spread | Moneyline | Total | | WEEK 1 | | San Diego Chargers | -5 | | | | Kansas City Chiefs | +5 | |
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